Enterprise AI Analysis
Development of a banana stem fiber-reinforced chitosan-xanthan gum wound healing patch loaded with Tridax procumbens extract for biomedical applications
This paper introduces a novel bio-composite wound healing patch, integrating banana pseudo stem fiber, chitosan, and xanthan gum with Tridax procumbens extract. Characterized for physicochemical properties, SEM reveals a slightly rough, uniformly dispersed fiber morphology; XRD shows a crystallinity index of ~78.43%; and FTIR validates active ingredient integration. Biologically, the patch demonstrates 60% antioxidant activity (IC50 ~7.67 µg/ml) and achieved 78% wound closure in L929 fibroblast cells within 24 hours at 25 µg/ml, with a 75% cell viability at 5 µg/ml. These findings highlight its potential as an effective wound healing material.
Executive Impact & Key Metrics
This novel bio-composite wound healing patch presents a significant opportunity for enterprises in the biomedical and healthcare sectors. Leveraging sustainable natural materials like banana stem fiber and Tridax procumbens extract, it offers a cost-effective, biocompatible, and highly effective solution for wound care. Its proven antioxidant and wound-healing properties, demonstrated by 78% wound closure within 24 hours and excellent cell viability, can drastically reduce treatment times and improve patient outcomes. This innovation streamlines the development of next-generation wound dressings, fostering market leadership and creating substantial ROI through accelerated product development and enhanced patient recovery.
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Antioxidant Activity (IC50)
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Wound Closure (24h)
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Cell Viability (MTT Assay)
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Crystallinity Index
Deep Analysis & Enterprise Applications
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Enterprise Process Flow: Fabrication Process
Preparation of Banana Pseudo Stem Fiber (BSF)
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Preparation of BSF-Chitosan/Xanthan Gum Patch (BSF-CG)
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Soxhlet Extraction from Tridax procumbens (TP)
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Drug-loaded BSF bio-composite patch
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Hydrogel Bio-functionalization of drug-loaded patch
78%
Achieved in L929 Fibroblast Cells within 24 hours at 25 µg/ml concentration.
| Comparison Feature | Our BSF+CG+TP Patch | Existing BSF-based Materials |
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| Antibacterial Activity |
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| Antioxidant Activity |
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| Wound Closure Efficacy (24h) |
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| Cell Viability (MTT Assay) |
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Interpenetrating Polymeric Network for Enhanced Wound Healing
The novel integration of Banana Stem Fiber (BSF), Chitosan, Xanthan gum, and Tridax procumbens extract into a hydrogel matrix forms an Interpenetrating Polymeric Network (IPN). This unique architecture allows for the synergistic benefits of each component, providing robust mechanical strength from BSF, biocompatibility and drug solubility from Chitosan-Xanthan gum, and sustained drug release from the Sodium alginate-Gaur gum hydrogel. This design addresses limitations of individual polymers, enhancing overall wound healing efficacy and stability against exudates.
78.43%
Indicates highly ordered molecular structure, enhancing mechanical strength and degradation control.
Next Steps for Clinical Translation
While in vitro results are highly encouraging, the next critical phases involve in-vivo testing in animal models to confirm wound healing efficacy, immune compatibility, and monitor inflammation, angiogenesis, and tissue remodeling. Future scope includes incorporating nano fabrication techniques for non-woven nanofiber mats and investigating nano biomaterials as drugs, along with understanding process condition effects on patch properties to open new avenues in nature-based wound healing material development.
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