Healthcare Innovation
The mediating role of fasting plasma glucose and systolic blood pressure in the association between Chinese visceral adiposity index and carotid atherosclerosis: a cross-sectional study
This analysis synthesizes key findings on the complex interplay between visceral adiposity, metabolic factors, and carotid atherosclerosis, offering crucial insights for preventive healthcare strategies.
Executive Impact: Strategic Insights for Healthcare Leaders
This study analyzed 6,767 adults, revealing a significant positive association between Chinese Visceral Adiposity Index (CVAI) and carotid atherosclerosis (CAS). Each standard deviation increase in CVAI corresponded to a 37% higher odds of CAS (OR 1.37, 95% CI 1.26-1.49). Crucially, Fasting Plasma Glucose (FPG) and Systolic Blood Pressure (SBP) were identified as parallel mediators, jointly explaining 59.2% of CVAI's total effect on CAS, with SBP contributing 36.0% and FPG 23.2%. A significant direct effect of 40.8% persisted. These findings highlight FPG and SBP as critical pathways linking visceral adiposity to atherosclerosis, suggesting that managing blood glucose and blood pressure is a core strategy for risk mitigation in individuals with elevated CVAI.
6,767
Participants Analyzed
37%
Increased CAS Risk per SD CVAI
59.2%
Total Effect Mediated (FPG & SBP)
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37%
Higher Odds of CAS per SD increase in CVAI (OR 1.37)
Mediating Pathways of Visceral Adiposity to Atherosclerosis
CVAI (Visceral Adiposity)
→
FPG (23.2% Mediation)
→
SBP (36.0% Mediation)
→
Carotid Atherosclerosis (CAS)
| Feature | Traditional Indices (BMI, WC) | Chinese Visceral Adiposity Index (CVAI) |
|---|---|---|
| Metabolic Activity |
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| Adipose Tissue Distribution |
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| Predictive Performance (Chinese Cohorts) |
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| Components |
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Clinical Implications & Risk Management
For individuals with elevated Chinese Visceral Adiposity Index (CVAI), an integrated approach to risk management is crucial. This study underscores the importance of rigorous monitoring and optimization of both fasting plasma glucose (FPG) and systolic blood pressure (SBP), alongside broader strategies for weight reduction, to effectively mitigate the risk of carotid atherosclerosis (CAS).
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