BrainVista: Modeling Naturalistic Brain Dynamics as Multimodal Next-Token Prediction
Revolutionizing fMRI Prediction with Causal AI
BrainVista, a novel multimodal autoregressive framework, addresses challenges in modeling naturalistic fMRI by introducing Network-wise Tokenizers for system-specific dynamics and a Spatial Mixer Head for inter-network information flow. It uses a Stimulus-to-Brain (S2B) masking mechanism to synchronize high-frequency sensory stimuli with hemodynamically filtered signals, enabling strict causal conditioning. Validated on Algonauts 2025, CineBrain, and HAD, BrainVista achieves state-of-the-art fMRI encoding performance and substantial improvements in long-horizon rollout settings, increasing pattern correlation by 36.0% and 33.3% respectively.
Key Impact & Performance Benchmarks
BrainVista sets new standards in naturalistic fMRI modeling and causal prediction, delivering robust performance across diverse datasets and critical metrics.
Deep Analysis & Enterprise Applications
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Enterprise Process Flow
| Feature | BrainVista | Existing Models |
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| Causal Prediction |
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| Multimodal Input |
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| Network Heterogeneity |
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| Long-Horizon Stability |
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Impact on Long-Horizon Rollout
BrainVista significantly improves long-horizon causal rollout, yielding more stable simulations of brain trajectories. This is crucial for applications requiring extended predictive capabilities, such as real-time neurofeedback or understanding dynamic cognitive processes over minutes. The model's structured approach to handling temporal dynamics and network interactions minimizes error accumulation, a common challenge in autoregressive forecasting.
- 36.0% pattern correlation increase on Algonauts 2025.
- 33.3% pattern correlation increase on CineBrain.
- Consistent improvements across various prediction horizons (H=1, H=10, H=20).
Predictive Neuroscience ROI Calculator
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BrainVista Implementation Roadmap
A phased approach to integrate BrainVista into your existing research or clinical workflow.
Phase 1: Data Preparation & Tokenization
Prepare fMRI data, extract multimodal stimuli features, and train Network-wise Tokenizers. Focus on aligning data to the fMRI grid and standardizing network-specific signals.
Phase 2: Causal Transformer Training
Train the temporal causal Transformer with S2B masking using the tokenized fMRI and stimulus data. Optimize for next-token prediction, ensuring strict past-only conditioning.
Phase 3: Spatial Mixer Integration & Fine-tuning
Integrate the Spatial Mixer Head to refine cross-network information flow. Fine-tune the entire BrainVista model for long-horizon rollout stability and inter-regional connectivity.
Phase 4: Validation & Application
Validate performance on held-out datasets (e.g., Algonauts, CineBrain) in open-loop rollout. Deploy for naturalistic fMRI prediction, real-time neurofeedback, or dynamic brain state simulation.
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